Cyclosporin A - Cyclosporin-A Protein
Produktgrößen
1gram
£218,00
OPPA01320-1GRAM
Über dieses Produkt
- SKU:
- OPPA01320
- Zusätzliche Namen:
- Cyclosporin A; Cyclosporin-A
- Konzentration:
- 1 mg/ml (prior to lyophilization)
- Weitere Details:
- Cyclosporin A is a noncytotoxic; natural; 11 amino acid cyclic peptide used clinically as an immunosuppressant for the treatment of autoimmune and inflammatory disorders and to prevent organ rejection after transplantation. Cyclosporin acts chiefly by inhibiting T lymphocyte function; which is vital for the propagation of inflammation. Cyclosporin A does not suppress the activity of other hematopoietic cells; does not cause bone marrow suppression and has a rapid onset of action as opposed to other immunosuppressive agents. Nevertheless; Cyclosporin A -induced nephrotoxicity remains an important clinical problem; and oxidative stress has been implicated as a potential responsible mechanism. Cyclosporin is a cyclic polypeptide immunosuppressant agent consisting of 11 amino acids. It is produced as a metabolite by the fungus species Beauveria nlyea. Chemically; cyclosporin is designated as [R-[R*;R*-(E)]]-cyclic(L-alanyl-D- alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N; 4-dimethyl-L-2-amino-6-octenoyl-L-*-amino-butyryl- N-methylglycyl-N- methyl-L-leucyl-L-valyl-N-methyl-L-leucyl).
- Molekulargewicht:
- 1202.64 Da
- Reinheit:
- Greater than 99.0% as determined by RP-HPLC
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized Cyclosporin A; although stable at room temperature for 3 weeks; should be stored desiccated below -18°C. Upon reconstitution Cyclosporin A should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles. It is recommended to reconstitute the lyophilized Cyclosporin-A in anhydrous ethanol R at a concentration of 50 mg/ml.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:html_datasheet.php