GM CSF Protein
Produktgrößen
5µg
£186,00
OPPA00486-5UG
Über dieses Produkt
- SKU:
- OPPA00486
- Zusätzliche Namen:
- CSF; GMCSF
- Weitere Details:
- Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) was first characterized as a growth factor that supports the in-vitro colony formation of granulocytes-macrophages progenitor cells. It is a pleiotropic cytokine and a member of a family of endogenous cytokines of the hematopoietic system. GM-CSF is produced as a response to immune or inflammatory stimuli by activated cells of the hematopoietic system such as T cells; B cells; macrophages; mast cells and also fibroblasts and alveolar epithelial cells. It plays an important role in regulating the proliferation; differentiation; survival and activation of hematopoietic cells such as granulocytes and monocytes ;neutrophiles; basophiles and eosonophoiles; erythroid cells; megakaryocytes and T cells. Human and mouse GM-CSF have about 56% homology and are species specific. Human GM-CSF is not active on mouse cells and vice versa. It is active on canine and feline cells. GMCSF is 144 amino acids; 22kDa glycoprotein. It is composed of four bundles alpha helices. Its receptor is heterodimers with a ligand-specific alpha subunit and a betac subunit that is shared with the interleukin IL-3 and IL-5 receptors. This unusual form of receptor assembly likely applies also to IL-3 and IL-5 receptors. Cross-linking the two receptor subunits is required for receptor activation and signaling . GMCSF has been shown to be involved in maturation; mobilization and antigen presentation of myeloid dentritic cells (DCs) in-vivo or ex-vivo. This function promotes Th1 immune responses; cytotoxcity; anti-angiogenesis as well as allergic inflammation; and the development of autoimmunity. Therefore GMCSF can be used in immunotherapy for the treatment of immune suppressed and immune-compromised patients as well as in veterinary medicine for the same purpose. GM-CSF is also important in regulation of embryo development and pregnancy and specifically in embryo implantation and subsequent development .
- Host:
- E. coli
- Molekulargewicht:
- 14 kDa
- Proteindetails:
- Granulocyte-macrophage colony-stimulating factor
- Reinheit:
- Greater than 98.0% as determined by:<br> a) Analysis by RP-HPLC<br> b) Analysis by SDS-PAGE
- Aufreinigung:
- Purified by proprietary chromatographic techniques
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- It is recommended to reconstitute the lyophilized Granulocyte Macrophage Colony Stimulating Factor in sterile 18M Omega -cm H2O not less than 100 ug/ml; which can then be further diluted to other aqueous solutions. Lyophilized Granulocyte Macrophage Colony Stimulating Factor although stable at room temperature for 3 weeks; should be stored desiccated below -18C. Upon reconstitution GMCSF should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0. 1% HSA or BSA). Please prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:html_datasheet.php