CBL Recombinant Protein
Produktgrößen
10ug
£268,00
OPCD06728-10UG
50ug
£511,00
OPCD06728-50UG
200ug
£918,00
OPCD06728-200UG
Über dieses Produkt
- SKU:
- OPCD06728
- Zusätzliche Namen:
- Cas-Br-M (murine) ecotropic retroviral transforming sequence;casitas B-lineage lymphoma proto-oncogene;Cbl proto-oncogene; E3 ubiquitin protein ligase;CBL2;C-CBL;E3 ubiquitin-protein ligase CBL;FRA11B;fragile site; folic acid type; rare; fra(11)(q23.3);NSLL;oncogene CBL2;proto-oncogene c-Cbl;RING finger protein 55;RING-type E3 ubiquitin transferase CBL;RNF55;signal transduction protein CBL.
- Konjugat:
- Unconjugated
- Konzentration:
- 200 ug/mL (prior to lyoph)
- Weitere Details:
- Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase; which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes; and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases; including KIT; FLT1; FGFR1; FGFR2; PDGFRA; PDGFRB; EGFR; CSF1R; EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK; SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.
- Gendetails:
- Cbl proto-oncogene
- Host:
- E. coli
- Molekulargewicht:
- 44kDa
- Proteindetails:
- E3 ubiquitin-protein ligase CBL
- Reinheit:
- > 95%
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php