GRK5 Recombinant Protein
Produktgrößen
10ug
£268,00
OPCD03686-10UG
50ug
£517,00
OPCD03686-50UG
200ug
£933,00
OPCD03686-200UG
Über dieses Produkt
- SKU:
- OPCD03686
- Zusätzliche Namen:
- FP2025;G protein-coupled receptor kinase 5;g protein-coupled receptor kinase GRK5;GPRK5.
- Konjugat:
- Unconjugated
- Konzentration:
- 200 ug/mL (prior to lyoph)
- Weitere Details:
- Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization; internalization; and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs; including adrenergic receptors; muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes); dopamine receptors and opioid receptors. In addition to GPCRs; also phosphorylates various substrates: Hsc70-interacting protein/ST13; TP53/p53; HDAC5; and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5; a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53; a crucial tumor suppressor; inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor; LRP6 during Wnt signaling (in vitro).
- Gendetails:
- G protein-coupled receptor kinase 5
- Host:
- E. coli
- Molekulargewicht:
- 30kDa
- Proteindetails:
- G protein-coupled receptor kinase 5
- Reinheit:
- > 95%
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php