GRIN2B Recombinant Protein
Produktgrößen
10ug
£257,00
OPCD03682-10UG
50ug
£489,00
OPCD03682-50UG
200ug
£879,00
OPCD03682-200UG
Über dieses Produkt
- SKU:
- OPCD03682
- Zusätzliche Namen:
- DEE27;EIEE27;GluN2B;GluN2B(alt_5'UTR);glutamate [NMDA] receptor subunit epsilon-2;glutamate receptor ionotropic; NMDA 2B;glutamate receptor subunit epsilon-2;glutamate receptor; ionotropic; N-methyl D-aspartate 2B;hNR3;MRD6;NMDAR2B;N-methyl D-aspartate receptor subtype 2B;N-methyl-D-aspartate receptor subunit 3;NR2B;NR3.
- Konjugat:
- Unconjugated
- Konzentration:
- 350 ug/mL (prior to lyoph)
- Weitere Details:
- Component of NMDA receptor complexes that function as heterotetrameric; ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit; glycine binding to the zeta subunit; plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735; PubMed:26919761; PubMed:26875626; PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:8768735; PubMed:26875626). In concert with DAPK1 at extrasynaptic sites; acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them; resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (By similarity).
- Gendetails:
- glutamate ionotropic receptor NMDA type subunit 2B
- Host:
- E. coli
- Molekulargewicht:
- 89kDa
- Proteindetails:
- Glutamate receptor ionotropic; NMDA 2B
- Reinheit:
- > 95%
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php