GRB10 Recombinant Protein
Produktgrößen
10ug
£261,00
OPCD03670-10UG
50ug
£500,00
OPCD03670-50UG
200ug
£901,00
OPCD03670-200UG
Über dieses Produkt
- SKU:
- OPCD03670
- Zusätzliche Namen:
- Grb-10;GRB10 adapter protein;GRB10 adaptor protein;GRB-IR;growth factor receptor-bound protein 10;insulin receptor-binding protein Grb-IR;IRBP;maternally expressed gene 1;MEG1;RSS.
- Konjugat:
- Unconjugated
- Konzentration:
- 200 ug/mL (prior to lyoph)
- Weitere Details:
- Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to; and suppress signals from; activated receptors tyrosine kinases; including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R; leading to IGF1R ubiquitination; increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR; leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.
- Gendetails:
- growth factor receptor bound protein 10
- Host:
- E. coli
- Molekulargewicht:
- 27kDa
- Proteindetails:
- Growth factor receptor-bound protein 10
- Reinheit:
- > 95%
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php