GPX4 Recombinant Protein
Produktgrößen
10ug
£279,00
OPCD03660-10UG
50ug
£543,00
OPCD03660-50UG
200ug
£994,00
OPCD03660-200UG
Über dieses Produkt
- SKU:
- OPCD03660
- Zusätzliche Namen:
- Glutathione peroxidase 4;GPx-4;GSHPx-4;mtPHG;mtPHGPx;PHG;PHGPx;phospholipid hydroperoxide glutathione peroxidase;phospholipid hydroperoxide glutathione peroxidase; mitochondrial;phospholipid hydroperoxide glutathione peroxidase; nuclear;sn;snGPx;sperm nuclei glutathione peroxidase.
- Konjugat:
- Unconjugated
- Konzentration:
- 200 ug/mL (prior to lyoph)
- Weitere Details:
- Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (PubMed:29290465). Can also reduce fatty acid hydroperoxide; cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (PubMed:12566075). Required to prevent cells from ferroptosis; a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (PubMed:12566075; PubMed:24439385; PubMed:25402683; PubMed:25922076; PubMed:29290465). The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (PubMed:29290465). The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons; thereby preventing against fatal epileptic seizures (PubMed:29290465). May be required to protect cells from the toxicity of ingested lipid hydroperoxides (PubMed:12566075). Required for normal sperm development and male fertility (PubMed:19783653; PubMed:25922076). Essential for maturation and survival of photoreceptor cells (PubMed:22207760). Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (PubMed:25824823).
- Gendetails:
- glutathione peroxidase 4
- Host:
- E. coli
- Molekulargewicht:
- 18kDa
- Proteindetails:
- Phospholipid hydroperoxide glutathione peroxidase
- Reinheit:
- > 95%
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php