CD36 Recombinant Protein
Produktgrößen
10ug
£301,00
OPCD03635-10UG
50ug
£593,00
OPCD03635-50UG
200ug
£1085,00
OPCD03635-200UG
Über dieses Produkt
- SKU:
- OPCD03635
- Zusätzliche Namen:
- Adipocyte membrane protein;Fatty acid translocase;Fatty acid transport protein;Glycoprotein IIIb;PAS IV;PAS-4;Platelet glycoprotein IV.
- Konjugat:
- Unconjugated
- Konzentration:
- 200 ug/mL (prior to lyoph)
- Weitere Details:
- Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin; fibronectin; collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL); anionic phospholipids; long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously; the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis; inflammatory response; fatty acid metabolism; taste and dietary fat processing in the intestine (By similarity) (PubMed:8320718). Binds long-chain fatty acids and facilitates their transport into cells; thus participating in muscle lipid utilization; adipose energy storage; and gut fat absorption (By similarity) (PubMed:8320718). In the small intestine; plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation; possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed:16276419; PubMed:21610069). Involved in oral fat perception and preferences (By similarity) (PubMed:16276419). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity) (PubMed:16276419). In taste receptor cells; mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids; leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity) (PubMed:23557700). Receptor for thombospondins; THBS1 and THBS2; mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4:TLR6 heterodimer; promotes inflammation in monocytes/macrophages. Upon ligand binding; such as oxLDL or amyloid-beta 42; interacts with the heterodimer TLR4:TLR6; the complex is internalized and triggers inflammatory response; leading to NF-kappa-B-dependent production of CXCL1; CXCL2 and CCL9 cytokines; via MYD88 signaling pathway; and CCL5 cytokine; via TICAM1 signaling pathway; as well as IL1B secretion; through the priming and activation of the NLRP3 inflammasome. Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer; this cluster triggers signaling from the cell surface; leading to the NF-kappa-B-dependent production of TNF; via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity).
- Host:
- E. coli
- Molekulargewicht:
- 28.45kDa
- Proteindetails:
- Platelet glycoprotein 4
- Reinheit:
- > 95%
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php