FGFR1 Recombinant Protein
Produktgrößen
10ug
£272,00
OPCD03213-10UG
50ug
£528,00
OPCD03213-50UG
200ug
£955,00
OPCD03213-200UG
Über dieses Produkt
- SKU:
- OPCD03213
- Zusätzliche Namen:
- basic fibroblast growth factor receptor 1;bFGF-R;bFGF-R-1;c-fgr;FGF receptor-1;FGFR-1;fibroblast growth factor receptor 1;MFR;proto-oncogene c-Fgr.
- Konjugat:
- Unconjugated
- Konzentration:
- 200 ug/mL (prior to lyoph)
- Weitere Details:
- Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development; cell proliferation; differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development; normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1; FRS2; GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1;4;5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2; GAB1; PIK3R1 and SOS1; and mediates activation of RAS; MAPK1/ERK2; MAPK3/ERK1 and the MAP kinase signaling pathway; as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1; STAT1 and PTPN11/SHP2. In the nucleus; enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF; and by FGFR1 ubiquitination; internalization and degradation (By similarity).
- Gendetails:
- Fibroblast growth factor receptor 1
- Host:
- E. coli
- Molekulargewicht:
- 48kDa
- Proteindetails:
- Fibroblast growth factor receptor 1
- Reinheit:
- > 95%
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php