FBXW7 Recombinant Protein
Produktgrößen
10ug
£283,00
OPCD03138-10UG
50ug
£561,00
OPCD03138-50UG
200ug
£1016,00
OPCD03138-200UG
Über dieses Produkt
- SKU:
- OPCD03138
- Zusätzliche Namen:
- 1110001A17Rik;A;AGO;Cdc4;F-box and WD-40 domain protein 7; archipelago homolog;F-box and WD-40 domain-containing protein 7;f-box only protein 30;F-box protein FBW7;F-box protein Fbxw6;F-box/WD repeat-containing protein 7;F-box-WD40 repeat protein 6;Fbw7;Fbwd6;Fbx30;Fbxo3;Fbxo30;Fbxw6;SEL-;SEL-10.
- Konjugat:
- Unconjugated
- Konzentration:
- 200 ug/mL (prior to lyoph)
- Weitere Details:
- Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21953459). Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (By similarity). Identified substrates include cyclin-E (CCNE1 or CCNE2); JUN; MYC; NOTCH1 released notch intracellular domain (NICD); NOTCH2; MCL1 and probably PSEN1 (By similarity). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (By similarity). SCF(FBXW7) complex mediates the ubiquitination and subsequent degradation of NFE2L1 (PubMed:21953459). Involved in bone homeostasis and negative regulation of osteoclast differentiation (PubMed:29149593).
- Gendetails:
- F-box and WD-40 domain protein 7
- Host:
- E. coli
- Molekulargewicht:
- 29.49kDa
- Proteindetails:
- F-box/WD repeat-containing protein 7
- Reinheit:
- > 95%
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php