FBXW7 Recombinant Protein
Produktgrößen
10ug
£272,00
OPCD03137-10UG
50ug
£528,00
OPCD03137-50UG
200ug
£955,00
OPCD03137-200UG
Über dieses Produkt
- SKU:
- OPCD03137
- Zusätzliche Namen:
- AGO;archipelago;Archipelago homolog;CDC4;F-box and WD repeat domain containing 7; E3 ubiquitin protein ligase;F-box and WD-40 domain protein 7 (archipelago homolog; Drosophila);F-box and WD-40 domain-containing protein 7;F-box protein FBW7;F-box protein FBX30;F-box protein SEL-10;F-box/WD repeat-containing protein 7;FBW6;FBW7;FBX30;FBXO30;FBXW6;hAgo;hCdc4;homolog of C elegans sel-10;SEL10;SEL-10.
- Konjugat:
- Unconjugated
- Konzentration:
- 200 ug/mL (prior to lyoph)
- Weitere Details:
- Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:17434132). Identified substrates include cyclin-E (CCNE1 or CCNE2); JUN; MYC; NOTCH1 released notch intracellular domain (NICD); NOTCH2; MCL1; and probably PSEN1 (PubMed:11565034; PubMed:12354302; PubMed:11585921; PubMed:15103331; PubMed:14739463; PubMed:17558397; PubMed:17873522; PubMed:22608923; PubMed:29149593; PubMed:25775507; PubMed:28007894). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463). SCF(FBXW7) complex mediates the ubiquitination and subsequent degradation of NFE2L1 (By similarity). Involved in bone homeostasis and negative regulation of osteoclast differentiation (PubMed:29149593).
- Gendetails:
- F-box and WD repeat domain containing 7
- Host:
- E. coli
- Molekulargewicht:
- 31kDa
- Proteindetails:
- F-box/WD repeat-containing protein 7
- Reinheit:
- > 95%
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php