EGFR Recombinant Protein
Produktgrößen
10ug
£261,00
OPCD02869-10UG
50ug
£500,00
OPCD02869-50UG
200ug
£901,00
OPCD02869-200UG
Über dieses Produkt
- SKU:
- OPCD02869
- Zusätzliche Namen:
- 9030024J15Rik;AI552599;avian erythroblastic leukemia viral (v-erb-b) oncogene homolog;epidermal growth factor receptor;Erb;Erbb;Err;Errb1;Errp;Wa;wa2;wa-2;Wa5;waved 2.
- Konjugat:
- Unconjugated
- Konzentration:
- 200 ug/mL (prior to lyoph)
- Weitere Details:
- Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:8404850). Known ligands include EGF; TGFA/TGF-alpha; AREG; epigen/EPGN; BTC/betacellulin; epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK; PI3 kinase-AKT; PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16; activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (By similarity). Plays a role in enhancing learning and memory performance (PubMed:20639532).
- Gendetails:
- epidermal growth factor receptor
- Host:
- E. coli
- Molekulargewicht:
- 23kDa
- Proteindetails:
- Epidermal growth factor receptor
- Reinheit:
- > 95%
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php