DDIT3 Recombinant Protein
Produktgrößen
10ug
£268,00
OPCD02688-10UG
50ug
£511,00
OPCD02688-50UG
200ug
£918,00
OPCD02688-200UG
Über dieses Produkt
- SKU:
- OPCD02688
- Zusätzliche Namen:
- AltDDIT3;alternative DDIT3 protein;C/EBP zeta;C/EBP-homologous protein;c/EBP-homologous protein 10;C/EBPzeta;CCAAT/enhancer-binding protein homologous protein;CEBPZ;CHOP;CHOP10;CHOP-10;DNA damage-inducible transcript 3 protein;GADD153;growth arrest and DNA damage-inducible protein GADD153.
- Konjugat:
- Unconjugated
- Konzentration:
- 200 ug/mL (prior to lyoph)
- Weitere Details:
- Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family; impairs their association with C/EBP binding sites in the promoter regions; and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3; IL6; IL8; IL23; TNFRSF10B/DR5; PPP1R15A/GADD34; BBC3/PUMA; BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1; ATF4-dependent transcriptional activation of asparagine synthetase (ASNS); CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4; impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
- Gendetails:
- DNA damage inducible transcript 3
- Host:
- E. coli
- Molekulargewicht:
- 32kDa
- Proteindetails:
- DNA damage-inducible transcript 3 protein
- Reinheit:
- > 95%
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php