DDB2 Recombinant Protein
Produktgrößen
10ug
£268,00
OPCD02685-10UG
50ug
£511,00
OPCD02685-50UG
200ug
£918,00
OPCD02685-200UG
Über dieses Produkt
- SKU:
- OPCD02685
- Zusätzliche Namen:
- damage-specific DNA binding protein 2; 48kDa;Damage-specific DNA-binding protein 2;DDB p48 subunit;DDBB;DNA damage-binding protein 2;UV-damaged DNA-binding protein 2;UV-DDB 2;UV-DDB2;xeroderma pigmentosum group E protein;XPE.
- Konjugat:
- Unconjugated
- Konzentration:
- 200 ug/mL (prior to lyoph)
- Weitere Details:
- Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD); 6-4 photoproducts (6-4 PP); apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A; histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC; which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA repair.
- Gendetails:
- damage specific DNA binding protein 2
- Host:
- E. coli
- Molekulargewicht:
- 28kDa
- Proteindetails:
- DNA damage-binding protein 2
- Reinheit:
- > 90%
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php