CLU Recombinant Protein
Produktgrößen
10ug
£246,00
OPCD02270-10UG
50ug
£463,00
OPCD02270-50UG
200ug
£825,00
OPCD02270-200UG
Über dieses Produkt
- SKU:
- OPCD02270
- Zusätzliche Namen:
- APOJ;CLI;clusterin;DAG;dimeric acid glycoprotein;RATTRPM2B;SGP2;SGP-2;SP40;SP-40;sulfated glycoprotein 2;testosterone repressed prostate message 2;testosterone-repressed prostate message;testostrone-repressed prostate message 2;Trpm2;TRPM-2;TRPM2B;Trpmb.
- Konjugat:
- Unconjugated
- Konzentration:
- 200 ug/mL (prior to lyoph)
- Weitere Details:
- Functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP; APOC2; B2M; CALCA; CSN3; SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones; such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted; protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Promotes apoptosis when in the nucleus. Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation (By similarity).
- Gendetails:
- clusterin
- Host:
- E. coli
- Molekulargewicht:
- 26kDa
- Proteindetails:
- Clusterin
- Reinheit:
- > 97%
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php