CDK8 Recombinant Protein
Produktgrößen
10ug
£268,00
OPCD02105-10UG
50ug
£517,00
OPCD02105-50UG
200ug
£929,00
OPCD02105-200UG
Über dieses Produkt
- SKU:
- OPCD02105
- Zusätzliche Namen:
- CDK8 protein kinase;cell division protein kinase 8;cyclin-dependent kinase 8;IDDHBA;K35;mediator complex subunit CDK8;mediator of RNA polymerase II transcription subunit CDK8;protein kinase K35.
- Konjugat:
- Unconjugated
- Konzentration:
- 150 ug/mL (prior to lyoph)
- Weitere Details:
- Component of the Mediator complex; a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II); which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH; leading to its degradation.
- Gendetails:
- cyclin dependent kinase 8
- Host:
- E. coli
- Molekulargewicht:
- 47kDa
- Proteindetails:
- Cyclin-dependent kinase 8
- Reinheit:
- >95%
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php