CD8B Recombinant Protein
Produktgrößen
10ug
£268,00
OPCD02047-10UG
50ug
£517,00
OPCD02047-50UG
200ug
£933,00
OPCD02047-200UG
Über dieses Produkt
- SKU:
- OPCD02047
- Zusätzliche Namen:
- CD8 antigen 37 kDa chain;CD8 antigen beta-chain;Cd8b1;OX-8 membrane antigen;T-cell surface glycoprotein CD8 beta chain.
- Konjugat:
- Unconjugated
- Konzentration:
- 200 ug/mL (prior to lyoph)
- Weitere Details:
- Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells; functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn; recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited; it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production; motility; adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally; plays a critical role in thymic selection of CD8+ T-cells.
- Gendetails:
- CD8b molecule
- Host:
- E. coli
- Molekulargewicht:
- 23kDa
- Proteindetails:
- T-cell surface glycoprotein CD8 beta chain
- Reinheit:
- > 90%
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php