CARD9 Recombinant Protein
Produktgrößen
10ug
£261,00
OPCD01865-10UG
50ug
£500,00
OPCD01865-50UG
200ug
£901,00
OPCD01865-200UG
Über dieses Produkt
- SKU:
- OPCD01865
- Zusätzliche Namen:
- CANDF2;caspase recruitment domain-containing protein 9;hCARD9.
- Konjugat:
- Unconjugated
- Konzentration:
- 200 ug/mL (prior to lyoph)
- Weitere Details:
- Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens; such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM-tyrosine kinase and the Toll-like receptors (TLR) and NOD2 signaling pathways. Probably controls various innate immune response pathways depending on the intracellular pathogen. In response to L.monocytogenes infection; acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B. Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK; while it is not required for TLR-induced activation of NF-kappa-B (By similarity). Controls CLEC7A (dectin-1)-mediated myeloid cell activation induced by the yeast cell wall component zymosan; leading to cytokine production and innate anti-fungal immunity: acts by regulating BCL10-MALT1-mediated NF-kappa-B activation pathway. Activates NF-kappa-B via BCL10. In response to the hyphal form of C.albicans; mediates CLEC6A (dectin-2)-induced I-kappa-B kinase ubiquitination; leading to NF-kappa-B activation via interaction with BCL10. In response to fungal infection; may be required for the development and subsequent differentiation of interleukin 17-producing T helper (TH-17) cells.
- Gendetails:
- caspase recruitment domain family member 9
- Host:
- E. coli
- Molekulargewicht:
- 31kDa
- Proteindetails:
- Caspase recruitment domain-containing protein 9
- Reinheit:
- > 95%
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php