BLK Recombinant Protein
Produktgrößen
10ug
£272,00
OPCD01647-10UG
50ug
£528,00
OPCD01647-50UG
200ug
£955,00
OPCD01647-200UG
Über dieses Produkt
- SKU:
- OPCD01647
- Zusätzliche Namen:
- b lymphocyte kinase;B lymphoid tyrosine kinase;BLK nonreceptor tyrosine kinase;MODY11;p55-Blk;tyrosine-protein kinase Blk.
- Konjugat:
- Unconjugated
- Konzentration:
- 200 ug/mL (prior to lyoph)
- Weitere Details:
- Non-receptor tyrosine kinase involved in B-lymphocyte development; differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases; and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition; as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199'; as well as CD79B at 'Tyr-196' and 'Tyr-207'. Phosphorylates also the immunoglobulin G receptors FCGR2A; FCGR2B and FCGR2C. With FYN and LYN; plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In pancreatic islets; acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose.
- Gendetails:
- BLK proto-oncogene; Src family tyrosine kinase
- Host:
- E. coli
- Molekulargewicht:
- 32.7kDa
- Proteindetails:
- Tyrosine-protein kinase Blk
- Reinheit:
- >95%
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php