AXIN1 Recombinant Protein
Produktgrößen
10ug
£268,00
OPCD01557-10UG
50ug
£522,00
OPCD01557-50UG
200ug
£940,00
OPCD01557-200UG
Über dieses Produkt
- SKU:
- OPCD01557
- Zusätzliche Namen:
- AXIN;axin-1;axis inhibition protein 1;axis inhibitor 1;fused; mouse; homolog of;PPP1R49;protein phosphatase 1; regulatory subunit 49.
- Konjugat:
- Unconjugated
- Konzentration:
- 200 ug/mL (prior to lyoph)
- Weitere Details:
- Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination; and modulating Wnt-signaling (PubMed:12192039; PubMed:27098453). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos; but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling; probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth; apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684).
- Gendetails:
- axin 1
- Host:
- E. coli
- Molekulargewicht:
- 27kDa
- Proteindetails:
- Axin-1
- Reinheit:
- > 95%
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php