AXIN1 Recombinant Protein
Produktgrößen
10ug
£261,00
OPCD01556-10UG
50ug
£506,00
OPCD01556-50UG
200ug
£907,00
OPCD01556-200UG
Über dieses Produkt
- SKU:
- OPCD01556
- Zusätzliche Namen:
- AI316800;Axin;axin-1;axis inhibition protein 1;Fu;fused;Kb;Ki;kinky;knobbly;protein Fused.
- Konjugat:
- Unconjugated
- Konzentration:
- 200 ug/mL (prior to lyoph)
- Weitere Details:
- Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination; and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos; but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling; probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (By similarity). Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth; apoptosis and development.
- Gendetails:
- axin 1
- Host:
- E. coli
- Molekulargewicht:
- 28kDa
- Proteindetails:
- Axin-1
- Reinheit:
- > 95%
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php