ATM Recombinant Protein
Produktgrößen
10ug
£268,00
OPCD01534-10UG
50ug
£511,00
OPCD01534-50UG
200ug
£918,00
OPCD01534-200UG
Über dieses Produkt
- SKU:
- OPCD01534
- Zusätzliche Namen:
- AT mutated;A-T mutated;AT1;ATA;ataxia telangiectasia mutated;ATC;ATD;ATDC;ATE;serine-protein kinase ATM;TEL1;TEL1; telomere maintenance 1; homolog;TELO1.
- Konjugat:
- Unconjugated
- Konzentration:
- 200 ug/mL (prior to lyoph)
- Weitere Details:
- Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs); apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA); thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs); thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion; a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele; acts by mediating a repositioning of the second allele to pericentromeric heterochromatin; preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2; CHEK2; p53/TP53; FANCD2; NFKBIA; BRCA1; CTIP; nibrin (NBN); TERF1; RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development; gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response.
- Gendetails:
- ATM serine/threonine kinase
- Host:
- E. coli
- Molekulargewicht:
- 60kDa
- Proteindetails:
- Serine-protein kinase ATM
- Reinheit:
- > 95%
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php