APP Recombinant Protein
Produktgrößen
10ug
£283,00
OPCD01454-10UG
50ug
£561,00
OPCD01454-50UG
200ug
£1016,00
OPCD01454-200UG
Über dieses Produkt
- SKU:
- OPCD01454
- Zusätzliche Namen:
- A;Abe;Abeta;Abpp;Adap;Ag;alzheimer disease amyloid A4 protein homolog;amyloid beta A4 protein;amyloid precursor protein;amyloid-beta A4 protein;amyloid-beta precursor protein;amyloidogenic glycoprotein;appican;bet;beta-amyloid precursor protein;betaApp;C;Cvap;E030013M08Rik;protease nexin II.
- Konjugat:
- Unconjugated
- Konzentration:
- 200 ug/mL (prior to lyoph)
- Weitere Details:
- Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth; neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor; mediating the axonal transport of beta-secretase and presenilin 1. May be involved in copper homeostasis/oxidative stress through copper ion reduction. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV (By similarity). The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK; resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons (By similarity). Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1.
- Gendetails:
- amyloid beta (A4) precursor protein
- Host:
- E. coli
- Molekulargewicht:
- 32kDa
- Proteindetails:
- Amyloid-beta A4 protein
- Reinheit:
- > 90%
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php