ANGPT1 Recombinant Protein
Produktgrößen
10ug
£294,00
OPCD01298-10UG
50ug
£576,00
OPCD01298-50UG
200ug
£1053,00
OPCD01298-200UG
Über dieses Produkt
- SKU:
- OPCD01298
- Zusätzliche Namen:
- 1110046O21Rik;an;Ang;Ang1;Ang-1;angiopoietin-1.
- Konjugat:
- Unconjugated
- Konzentration:
- 200 ug/mL (prior to lyoph)
- Weitere Details:
- Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis; endothelial cell survival; proliferation; migration; adhesion and cell spreading; reorganization of the actin cytoskeleton; but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth; activates or inhibits angiogenesis; depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels; where endothelial cells have tight contacts. In quiescent vessels; ANGPT1 oligomers recruit TEK to cell-cell contacts; forming complexes with TEK molecules from adjoining cells; and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions; ANGT1 recruits TEK to contacts with the extracellular matrix; leading to the formation of focal adhesion complexes; activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1; and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme (By similarity).
- Gendetails:
- angiopoietin 1
- Host:
- E. coli
- Molekulargewicht:
- 20kDa
- Proteindetails:
- Angiopoietin-1
- Reinheit:
- > 95%
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php