ADAM10 Recombinant Protein
Produktgrößen
10ug
£272,00
OPCD01078-10UG
50ug
£528,00
OPCD01078-50UG
200ug
£955,00
OPCD01078-200UG
Über dieses Produkt
- SKU:
- OPCD01078
- Zusätzliche Namen:
- a disintegrin and metalloprotease domain 10;AD10;AD18;CD156c;CDw156;disintegrin and metalloproteinase domain-containing protein 10;HsT18717;kuz;kuzbanian protein homolog;MADM;mammalian disintegrin-metalloprotease;RAK.
- Konjugat:
- Unconjugated
- Konzentration:
- 200 ug/mL (prior to lyoph)
- Weitere Details:
- Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins; including heparin-binding epidermal growth-like factor; ephrin-A2; CD44; CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:26686862; PubMed:11786905; PubMed:29224781). Contributes to the normal cleavage of the cellular prion protein (PubMed:11477090). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles; suggesting a vesicle-based protease activity (PubMed:12475894). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (PubMed:17557115). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (PubMed:19114711; PubMed:21288900). May regulate the EFNA5-EPHA3 signaling (PubMed:16239146).
- Gendetails:
- ADAM metallopeptidase domain 10
- Host:
- E. coli
- Molekulargewicht:
- 30kDa
- Proteindetails:
- Disintegrin and metalloproteinase domain-containing protein 10
- Reinheit:
- > 95%
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php