ERCC2 Recombinant Protein
Produktgrößen
10ug
£251,00
OPCD00899-10UG
50ug
£485,00
OPCD00899-50UG
200ug
£864,00
OPCD00899-200UG
Über dieses Produkt
- SKU:
- OPCD00899
- Zusätzliche Namen:
- basic transcription factor 2 80 kDa subunit;BTF2 p80;COFS2;CXPD;DNA excision repair protein ERCC-2;DNA repair protein complementing XP-D cells;EM9;excision repair cross-complementation group 2;excision repair cross-complementing rodent repair deficiency; complementation group 2;general transcription and DNA repair factor IIH helicase subunit XPD;TFIIH;TFIIH 80 kDa subunit;TFIIH basal transcription factor complex 80 kDa subunit;TFIIH basal transcription factor complex helicase subunit;TFIIH basal transcription factor complex helicase XPB subunit;TFIIH basal transcription factor complex helicase XPD subunit;TFIIH p80;TFIIH subunit XPD;TTD;TTD1;xeroderma pigmentosum complementary group D;xeroderma pigmentosum group D-complementing protein;XPD.
- Konjugat:
- Unconjugated
- Konzentration:
- 200 ug/mL (prior to lyoph)
- Weitere Details:
- ATP-dependent 5'-3' DNA helicase; component of the general transcription and DNA repair factor IIH (TFIIH) core complex; which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and; when complexed to CAK; in RNA transcription by RNA polymerase II. In NER; TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/ERCC2 is required for DNA opening. In transcription; TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established; TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. XPD/ERCC2 acts by forming a bridge between CAK and the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.
- Gendetails:
- ERCC excision repair 2; TFIIH core complex helicase subunit
- Host:
- E. coli
- Molekulargewicht:
- 27kDa
- Proteindetails:
- General transcription and DNA repair factor IIH helicase subunit XPD
- Reinheit:
- > 95%
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php