EPRS Recombinant Protein
Produktgrößen
10ug
£261,00
OPCD00360-10UG
50ug
£500,00
OPCD00360-50UG
200ug
£897,00
OPCD00360-200UG
Über dieses Produkt
- SKU:
- OPCD00360
- Zusätzliche Namen:
- 2410081F06Rik;3010002K18Rik;bifunctional aminoacyl-tRNA synthetase;bifunctional glutamate/proline--tRNA ligase;C79379;Eprs1;glutamine-proline-tRNA synthetase;Q;Qprs.
- Konjugat:
- Unconjugated
- Konzentration:
- 200 ug/mL (prior to lyoph)
- Weitere Details:
- Multifunctional protein which is primarily part of the aminoacyl-tRNA synthetase multienzyme complex; also know as multisynthetase complex; that catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA (By similarity). The phosphorylation of EPRS; induced by interferon-gamma; dissociates the protein from the aminoacyl-tRNA synthetase multienzyme complex and recruits it to the GAIT complex that binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin); suppressing their translation. Interferon-gamma can therefore redirect; in specific cells; the EPRS function from protein synthesis to translation inhibition (PubMed:23071094). Also functions as an effector of the mTORC1 signaling pathway by promoting; through SLC27A1; the uptake of long-chain fatty acid by adipocytes. Thereby; it also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239).
- Gendetails:
- glutamyl-prolyl-tRNA synthetase
- Host:
- E. coli
- Molekulargewicht:
- 61kDa
- Proteindetails:
- Bifunctional glutamate/proline--tRNA ligase
- Reinheit:
- > 90%
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php