ACE2 Recombinant Protein
Produktgrößen
20ug
£402,00
OPCA335985-20UG
100ug
£875,00
OPCA335985-100UG
Über dieses Produkt
- SKU:
- OPCA335985
- Zusätzliche Namen:
- ACEH;ACE-related carboxypeptidase;angiotensin I converting enzyme (peptidyl-dipeptidase A) 2;angiotensin I converting enzyme 2;angiotensin-converting enzyme 2;angiotensin-converting enzyme homolog;angiotensin-converting enzyme-related carboxypeptidase;metalloprotease MPROT15;peptidyl-dipeptidase A;truncated angiotensin converting enzyme 2.
- Weitere Details:
- Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume; systemic vascular resistance; and thus cardiovascular homeostasis (PubMed:27217402). Converts angiotensin I to angiotensin 1-9; a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes; and angiotensin II to angiotensin 1-7; which then acts as a beneficial vasodilator and anti-proliferation agent; counterbalancing the actions of the vasoconstrictor angiotensin II (PubMed:10969042; PubMed:10924499; PubMed:11815627; PubMed:19021774; PubMed:14504186). Also removes the C-terminal residue from three other vasoactive peptides; neurotensin; kinetensin; and des-Arg bradykinin; but is not active on bradykinin (PubMed:10969042; PubMed:11815627). Also cleaves other biological peptides; such as apelins (apelin-13; [Pyr1]apelin-13; apelin-17; apelin-36); casomorphins (beta-casomorphin-7; neocasomorphin) and dynorphin A with high efficiency (PubMed:11815627; PubMed:27217402; PubMed:28293165). In addition; ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction; regulating its expression on the cell surface and its catalytic activity (PubMed:18424768; PubMed:19185582).
- Gendetails:
- angiotensin converting enzyme 2
- Molekulargewicht:
- 112.5 kDa
- Proteindetails:
- Angiotensin-converting enzyme 2
- Reinheit:
- Greater than 85% as determined by SDS-PAGE.
- Aufreinigung:
- Affinity purified using IMAC
- Versandbedingungen:
- Blue Ice
- Quelle:
- Mammalian Cells
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php