CRBN Recombinant Protein
Produktgrößen
20ug
£1085,00
OPCA05324-20UG
100ug
£1384,00
OPCA05324-100UG
Über dieses Produkt
- SKU:
- OPCA05324
- Zusätzliche Namen:
- MRT2;MRT2A;protein cereblon;protein x 0001.
- Weitere Details:
- Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins; such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein; leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC; IRF4; IKZF1 and IKZF3.
- Gendetails:
- cereblon
- Molekulargewicht:
- 54.5 kDa
- Proteindetails:
- Protein cereblon
- Reinheit:
- Greater than 90% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php