EIF3E Recombinant Protein
Produktgrößen
20ug
£463,00
OPCA04735-20UG
100ug
£652,00
OPCA04735-100UG
1mg
£2446,00
OPCA04735-1MG
Über dieses Produkt
- SKU:
- OPCA04735
- Zusätzliche Namen:
- eIF-3 p48;eIF3-p46;EIF3-P48;EIF3S6;eukaryotic translation initiation factor 3 subunit 6;eukaryotic translation initiation factor 3 subunit E;eukaryotic translation initiation factor 3; subunit 6 (48kD);eukaryotic translation initiation factor 3; subunit 6 48kDa;INT6;mammary tumor-associated protein INT6;murine mammary tumor integration site 6 (oncogene homolog);viral integration site protein INT-6 homolog.
- Konzentration:
- Varies by lot. See vial for exact concentration.
- Weitere Details:
- Component of the eukaryotic translation initiation factor 3 (eIF-3) complex; which is required for several steps in the initiation of protein synthesis (PubMed:17581632; PubMed:25849773; PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1; eIF-1A; eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation; including cell cycling; differentiation and apoptosis; and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway (PubMed:17468741). May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins (PubMed:17310990; PubMed:17324924).
- Gendetails:
- eukaryotic translation initiation factor 3 subunit E
- Molekulargewicht:
- 79.1 kDa
- Proteindetails:
- Eukaryotic translation initiation factor 3 subunit E
- Reinheit:
- Greater than 90% as determined by SDS-PAGE.
- Aufreinigung:
- Affinity purified using AC
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php