DCTN1 Recombinant Protein
Produktgrößen
20ug
£348,00
OPCA04679-20UG
100ug
£500,00
OPCA04679-100UG
1mg
£1822,00
OPCA04679-1MG
Über dieses Produkt
- SKU:
- OPCA04679
- Zusätzliche Namen:
- 150 kDa dynein-associated polypeptide;DAP-150;DP-150;dynactin 1 (p150; glued homolog; Drosophila);dynactin subunit 1;P135;p150-glued.
- Weitere Details:
- Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos; microtubules and dynein. Essential for targeting dynein to microtubule plus ends; recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation; nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin; leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitement to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020).
- Gendetails:
- dynactin subunit 1
- Molekulargewicht:
- 55.2 kDa
- Proteindetails:
- Dynactin subunit 1
- Reinheit:
- Greater than 90% as determined by SDS-PAGE.
- Aufreinigung:
- Affinity purified using IMAC
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php