Delta-theraphotoxin-Hm1a Recombinant Protein
Produktgrößen
20ug
£561,00
OPCA04656-20UG
100ug
£793,00
OPCA04656-100UG
1mg
£2446,00
OPCA04656-1MG
Über dieses Produkt
- SKU:
- OPCA04656
- Zusätzliche Namen:
- Heteroscodratoxin-1;Kappa-theraphotoxin-Hm1a.
- Weitere Details:
- Gating modifier toxin that principally inhibits inactivation of the mammalian voltage-gated sodium channel Nav1.1/SCN1A. When tested against human Nav1.1/SCN1A-Nav1.8/SCN10A alpha subunits heterologously expressed in Xenopus oocytes; the toxin inhibits inactivation of Nav1.1 (EC(50)=38 nM); with substantially weaker effects on Nav1.2/SCN2A (EC(50)=236 nM) and Nav1.3/SCN3A (EC(50)=220 nM). The toxin inhibits several subtypes of voltage-gated potassium channels with significantly lower potency than its effects on Nav1.1/SCN1A (PubMed:27281198). It is a moderately potent blocker of Kv2.1/KCNB1; Kv2.2/KCNB2; Kv4.1/KCND1; Kv4.2/KCND2 and Kv4.3/KCND3 and has little effect on Kv1.1/KCNA1; Kv1.2/KCNA2; Kv1.3/KCNA3; Kv1.4/KCNA4; Kv1.5/KCNA5; Kv1.6/KCNA6 and Kv3.4/KCNC4 (PubMed:12065754). The binding affinity and subtype selectivity of the toxin is determined by residues within both the S1-S2 and S3-S4 loops of the domain IV voltage sensor (PubMed:27281198). Intracerebroventricular injection into mice elicits convulsions; spasms; tremors and rapid death (PubMed:12065754). When injected into mouse hindpaw; the toxin elicits an immediate and robust response to pain (PubMed:27281198). Intraplantar injection of toxin does not cause neurogenic inflammation or alter sensitivity to heat; indicative of a modality-specific effect on mechanosensitive neurons (PubMed:27281198).
- Molekulargewicht:
- 24 kDa
- Proteindetails:
- Delta-theraphotoxin-Hm1a
- Reinheit:
- Greater than 90% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php