CLEC4E Recombinant Protein
Produktgrößen
20ug
£561,00
OPCA04325-20UG
100ug
£793,00
OPCA04325-100UG
1mg
£2446,00
OPCA04325-1MG
Über dieses Produkt
- SKU:
- OPCA04325
- Zusätzliche Namen:
- C86253;Clecs;Clecsf9;C-type (calcium dependent; carbohydrate recognition domain) lectin; superfamily member 9;C-type lectin domain family 4 member E;C-type lectin superfamily member 9;C-type lectin; superfamily member 9;macrophage-inducible C-type lectin;Min;Mincle.
- Weitere Details:
- A calcium-dependent lectin that acts as a pattern recognition receptor of the innate immune system. Recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi (PubMed:18509109; PubMed:19171887; PubMed:23602766; PubMed:18776906). The PAMPs notably include mycobacterial trehalose 6;6'-dimycolate (TDM); a cell wall glycolipid with potent adjuvant immunomodulatory functions (PubMed:23602766). Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells (PubMed:23602766; PubMed:18776906). Binding of mycobacterial trehalose 6;6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G; triggering activation of SYK; CARD9 and NF-kappa-B; consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (PubMed:23602766). Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia and mediates macrophage activation (PubMed:19171887). Through recognition of DAMPs released upon nonhomeostatic cell death; enables immune sensing of damaged self and promotes inflammatory cell infiltration into the damaged tissue (PubMed:18776906).
- Gendetails:
- C-type lectin domain family 4; member e
- Molekulargewicht:
- 23.6 kDa
- Proteindetails:
- C-type lectin domain family 4 member E
- Reinheit:
- Greater than 90% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php