CSNK2A1 Recombinant Protein
Produktgrößen
20ug
£348,00
OPCA04008-20UG
100ug
£500,00
OPCA04008-100UG
1mg
£1822,00
OPCA04008-1MG
Über dieses Produkt
- SKU:
- OPCA04008
- Zusätzliche Namen:
- casein kinase 2; alpha 1 polypeptide;casein kinase II alpha 1 polypeptide pseudogene;casein kinase II alpha 1 subunit;casein kinase II subunit alpha;CK2 catalytic subunit alpha;CK2A1;Cka1;Cka2;CKII;OCNDS;protein kinase CK2.
- Weitere Details:
- Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes; such as cell cycle progression; apoptosis and transcription; as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis; functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis; phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8; and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I; II; III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B; STAT1; CREB1; IRF1; IRF2; ATF1; SRF; MAX; JUN; FOS; MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37; which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection; phosphorylates various proteins involved in the viral life cycles of EBV; HSV; HBV; HCV; HIV; CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (PubMed:11239457; PubMed:11704824; PubMed:16193064; PubMed:19188443; PubMed:20625391; PubMed:22406621). Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue (PubMed:24962073).
- Gendetails:
- casein kinase 2 alpha 1
- Molekulargewicht:
- 56.7 kDa
- Proteindetails:
- Casein kinase II subunit alpha
- Reinheit:
- Greater than 90% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php