ACKR3 Recombinant Protein
Produktgrößen
20ug
£348,00
OPCA03471-20UG
100ug
£500,00
OPCA03471-100UG
1mg
£1822,00
OPCA03471-1MG
Über dieses Produkt
- SKU:
- OPCA03471
- Zusätzliche Namen:
- atypical chemokine receptor 3;chemokine (C-X-C motif) receptor 7;chemokine orphan receptor 1;CMKOR1;C-X-C chemokine receptor type 7;CXCR7;CXCR-7;CXC-R7;G protein-coupled receptor;GPR159;G-protein coupled receptor 159;G-protein coupled receptor RDC1 homolog;RDC1;RDC-1.
- Weitere Details:
- Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades; resulting instead in chemokine sequestration; degradation; or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment; leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons; thereby adapting their chemokine responsiveness. In glioma cells; transduces signals via MEK/ERK pathway; mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration; adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells; leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.
- Gendetails:
- atypical chemokine receptor 3
- Host:
- Human
- Molekulargewicht:
- 20.5 kDa
- Proteindetails:
- Atypical chemokine receptor 3
- Reinheit:
- Greater than 90% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php