E7 Recombinant Protein
Produktgrößen
20ug
£398,00
OPCA02947-20UG
100ug
£550,00
OPCA02947-100UG
Über dieses Produkt
- SKU:
- OPCA02947
- Zusätzliche Namen:
- E7Protein E7
- Konzentration:
- Varies by lot. See vial for exact concentration.
- Weitere Details:
- Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1; with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2; leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:26405230).
- Host:
- Human
- Molekulargewicht:
- 14 kDa
- Proteindetails:
- Protein E7
- Reinheit:
- Greater than 90% as determined by SDS-PAGE.
- Aufreinigung:
- Affinity purified using IMAC
- Versandbedingungen:
- Blue Ice
- Quelle:
- Yeast
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php