Ctcfl Recombinant Protein
Produktgrößen
20ug
£463,00
OPCA02635-20UG
100ug
£727,00
OPCA02635-100UG
1mg
£2776,00
OPCA02635-1MG
Über dieses Produkt
- SKU:
- OPCA02635
- Zusätzliche Namen:
- B;BORIS;Brother of the regulator of imprinted sites;CCCTC-binding factor;CTCF paralog;CTCF-like protein;likely orthologue of H. sapiens CCCTC-binding factor-like protein (CTCFL);transcriptional repressor CTCFL.
- Weitere Details:
- Testis-specific DNA binding protein responsible for insulator function; nuclear architecture and transcriptional control; which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline; by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase; leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites. Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B; involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.
- Gendetails:
- CCCTC-binding factor (zinc finger protein)-like
- Host:
- Mouse
- Molekulargewicht:
- 75.1 kDa
- Proteindetails:
- Transcriptional repressor CTCFL
- Reinheit:
- Greater than 90% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Quelle:
- Yeast
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php