FZR1 Recombinant Protein
Produktgrößen
20ug
£348,00
OPCA02549-20UG
100ug
£500,00
OPCA02549-100UG
1mg
£1822,00
OPCA02549-1MG
Über dieses Produkt
- SKU:
- OPCA02549
- Zusätzliche Namen:
- CDC20 homolog 1;CDC20C;CDC20-like 1b;CDC20-like protein 1;CDH1;cdh1/Hct1 homolog;fizzy/cell division cycle 20 related 1;fizzy-related protein homolog;FZR;FZR2;HCDH;HCDH1.
- Konzentration:
- Varies by lot. See vial for concentration.
- Weitere Details:
- Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis; in replacement of CDC20; and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated; leading to its dissociation from the APC/C. Following DNA damage; it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1; preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover; may play a role in DNA damage response; favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free; RBBP8-mediated homologous recombination (HR) (PubMed:25349192).
- Gendetails:
- fizzy and cell division cycle 20 related 1
- Host:
- Human
- Molekulargewicht:
- 70.8 kDa
- Proteindetails:
- Fizzy-related protein homolog
- Reinheit:
- Greater than 90% as determined by SDS-PAGE.
- Aufreinigung:
- Affinity purified using IMAC
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php