FBXL2 Recombinant Protein
Produktgrößen
20ug
£348,00
OPCA02546-20UG
100ug
£500,00
OPCA02546-100UG
1mg
£1822,00
OPCA02546-1MG
Über dieses Produkt
- SKU:
- OPCA02546
- Zusätzliche Namen:
- FBL2;FBL3;F-box and leucine-rich repeat protein 2;F-box protein containing leucine-rich repeats;F-box protein FBL2/FBL3;F-box/LRR-repeat protein 2.
- Konzentration:
- Varies by lot. See vial for exact concentration.
- Weitere Details:
- Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex; SCF(FBXL2); which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins; FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) (PubMed:22020328; PubMed:22323446). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine; which is utilized for formation of membranes and of pulmonary surfactant (By similarity).
- Gendetails:
- F-box and leucine rich repeat protein 2
- Molekulargewicht:
- 63.1 kDa
- Proteindetails:
- F-box/LRR-repeat protein 2
- Reinheit:
- Greater than 90% as determined by SDS-PAGE.
- Aufreinigung:
- Affinity purified using IMAC
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php