CHCHD4 Recombinant Protein
Produktgrößen
20ug
£348,00
OPCA02425-20UG
100ug
£500,00
OPCA02425-100UG
1mg
£1822,00
OPCA02425-1MG
Über dieses Produkt
- SKU:
- OPCA02425
- Zusätzliche Namen:
- coiled-coil-helix-coiled-coil-helix domain-containing protein 4;MIA40;mitochondrial intermembrane space import and assembly protein 40;TIMM40;translocase of inner mitochondrial membrane 40 homolog.
- Weitere Details:
- Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins; such as COX17; COX19 and MICU1 (PubMed:16185709; PubMed:26387864; PubMed:19182799; PubMed:21059946; PubMed:23186364; PubMed:23676665). Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein; resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (PubMed:16185709; PubMed:19182799; PubMed:21059946; PubMed:23676665). Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system (PubMed:23186364). Mediates formation of disulfide bond in MICU1 in the IMS; promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake (PubMed:26387864).
- Gendetails:
- coiled-coil-helix-coiled-coil-helix domain containing 4
- Host:
- Human
- Molekulargewicht:
- 32 kDa
- Proteindetails:
- Mitochondrial intermembrane space import and assembly protein 40
- Reinheit:
- Greater than 90% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php