ALKBH3 Recombinant Protein
Produktgrößen
20ug
£348,00
OPCA02417-20UG
100ug
£500,00
OPCA02417-100UG
1mg
£1822,00
OPCA02417-1MG
Über dieses Produkt
- SKU:
- OPCA02417
- Zusätzliche Namen:
- ABH3;alkB homolog 3; alpha-ketoglutaratedependent dioxygenase;alkB; alkylation repair homolog 3;alkylated DNA repair protein alkB homolog 3;alpha-ketoglutarate-dependent dioxygenase alkB homolog 3;DEPC1;DEPC-1;hABH3;PCA1;Prostate cancer antigen 1;prostate cancer antigen-1.
- Weitere Details:
- Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A) (PubMed:12486230; PubMed:12594517; PubMed:16174769; PubMed:26863196; PubMed:26863410). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation (PubMed:12486230; PubMed:12594517; PubMed:16174769; PubMed:25944111). Has a strong preference for single-stranded DNA (PubMed:12486230; PubMed:12594517; PubMed:16174769). Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3; which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3 (PubMed:22055184). Also acts on RNA (PubMed:12594517; PubMed:16174769; PubMed:26863196; PubMed:26863410; PubMed:16858410). Demethylates N(1)-methyladenosine (m1A) RNA; an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons (PubMed:26863196; PubMed:26863410). Requires molecular oxygen; alpha-ketoglutarate and iron (PubMed:22055184; PubMed:16858410).
- Gendetails:
- alkB homolog 3; alpha-ketoglutarate dependent dioxygenase
- Host:
- Human
- Molekulargewicht:
- 35.3 kDa
- Proteindetails:
- Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
- Reinheit:
- Greater than 90% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php