ARHGAP19 Recombinant Protein
Produktgrößen
20ug
£348,00
OPCA02265-20UG
100ug
£500,00
OPCA02265-100UG
1mg
£1822,00
OPCA02265-1MG
Über dieses Produkt
- SKU:
- OPCA02265
- Zusätzliche Namen:
- BAF47;BRG1-associated factor 47;CSS3;hSNF5;hSNFS;INI1;integrase interactor 1 protein;malignant rhabdoid tumor suppressor;MRD15;PPP1R144;protein phosphatase 1; regulatory subunit 144;RDT;RTPS1;Sfh1p;SNF5;SNF5 homolog;SNF5L1;Snr1;sucrose nonfermenting; yeast; homolog-like 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;SWI/SNF-related matrix-associated protein;SWNTS1.
- Weitere Details:
- Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation; in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable; altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures; termed altosomes; each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons; npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A; are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1.
- Gendetails:
- SWI/SNF related; matrix associated; actin dependent regulator of chromatin; subfamily b; member 1
- Host:
- Human
- Molekulargewicht:
- 60.1 kDa
- Proteindetails:
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
- Reinheit:
- Greater than 90% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php