CBFB Recombinant Protein
Produktgrößen
20ug
£348,00
OPCA02263-20UG
100ug
£500,00
OPCA02263-100UG
1mg
£1822,00
OPCA02263-1MG
Über dieses Produkt
- SKU:
- OPCA02263
- Zusätzliche Namen:
- CBF-beta;core-binding factor beta subunit;core-binding factor subunit beta;PEA2-beta;PEBP2B;PEBP2-beta;polyomavirus enhancer binding protein 2; beta subunit;Polyomavirus enhancer-binding protein 2 beta subunit;SL3/AKV core-binding factor beta subunit;SL3-3 enhancer factor 1 beta subunit;SL3-3 enhancer factor 1 subunit beta.
- Weitere Details:
- Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1; RUNX2; and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3'; or very rarely; 5'-TGCGGT-3'; within their regulatory regions via their runt domain; while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters; including murine leukemia virus; polyomavirus enhancer; T-cell receptor enhancers; LCK; IL3 and GM-CSF promoters. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation.
- Gendetails:
- core-binding factor subunit beta
- Host:
- Human
- Molekulargewicht:
- 37.5 kDa
- Proteindetails:
- Core-binding factor subunit beta
- Reinheit:
- Greater than 90% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php