FAM175B Recombinant Protein
Produktgrößen
20ug
£348,00
OPCA02247-20UG
100ug
£500,00
OPCA02247-100UG
1mg
£1822,00
OPCA02247-1MG
Über dieses Produkt
- SKU:
- OPCA02247
- Zusätzliche Namen:
- abraxas brother 1;abraxas brother protein 1;ABRO1;BRISC complex subunit Abraxas 2;BRISC complex subunit Abro1;FAM175B;family with sequence similarity 175 member B;KIAA0157;Protein FAM175B.
- Weitere Details:
- Component of the BRISC complex; a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin; leaving the last ubiquitin chain attached to its substrates (PubMed:19214193; PubMed:20032457; PubMed:20656690; PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985; PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex; promotes interaction between USP7 and p53/TP53; and thereby promotes deubiquitination of p53/TP53; preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148).
- Gendetails:
- abraxas 2; BRISC complex subunit
- Host:
- Human
- Molekulargewicht:
- 73.9 kDa
- Proteindetails:
- BRISC complex subunit Abraxas 2
- Reinheit:
- Greater than 90% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php