Con-ikot-ikot Recombinant Protein
Produktgrößen
20ug
£561,00
OPCA01987-20UG
100ug
£793,00
OPCA01987-100UG
1mg
£2446,00
OPCA01987-1MG
Über dieses Produkt
- SKU:
- OPCA01987
- Zusätzliche Namen:
- Con-ikot-ikot
- Weitere Details:
- Potently and selectively blocks the desensitization of ionotropic glutamate AMPA receptor (GRIA1; GRIA2; GRIA3 and GRIA4). Can also open already desensitized GRIA1 receptors. Binds to a different site than does the drug cyclothiazide (PubMed:19481459). The toxin acts like a straightjacket on the ligand-binding domain (LBD) "gating ring" of the receptor; restraining the domains via both intra- and interdimer cross-links such that agonist-induced closure of the LBD "clamshells" is transduced into an irislike expansion of the gating ring (PubMed:25103405). Application of the toxin to hippocampal slices causes a large and rapid increase in resting AMPAR-mediated current leading to neuronal death (PubMed:19481459).
- Molekulargewicht:
- 13.4 kDa
- Proteindetails:
- Con-ikot-ikot
- Reinheit:
- Greater than 90% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php