CSRP3 Recombinant Protein
Produktgrößen
20ug
£348,00
OPCA01544-20UG
100ug
£500,00
OPCA01544-100UG
1mg
£1822,00
OPCA01544-1MG
Über dieses Produkt
- SKU:
- OPCA01544
- Zusätzliche Namen:
- cardiac LIM domain protein;Cardiac LIM protein;CLP;CMD1M;CMH12;CRP3;cysteine and glycine-rich protein 3;cysteine and glycine-rich protein 3 (cardiac LIM protein);Cysteine-rich protein 3;LIM domain only 4;LIM domain protein; cardiac;LMO4;MLP;Muscle LIM protein.
- Weitere Details:
- Positive regulator of myogenesis. Acts as cofactor for myogenic bHLH transcription factors such as MYOD1; and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (By similarity). Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity). The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly: Shown to enhance CFL2-mediated F-actin depolymerization dependent on the CSRP3:CFL2 molecular ratio; and also shown to reduce the ability of CLF1 and CFL2 to enhance actin depolymerization (PubMed:19752190; PubMed:24934443). Proposed to contribute to the maintenance of muscle cell integerity through an actin-based mechanism. Can directly bind to actin filaments; cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association (PubMed:24934443). In vitro can inhibit PKC/PRKCA activity (PubMed:27353086). Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling (By similarity).
- Gendetails:
- cysteine and glycine rich protein 3
- Host:
- Human
- Molekulargewicht:
- 37 kDa
- Proteindetails:
- Cysteine and glycine-rich protein 3
- Reinheit:
- Greater than 90% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php