ATP2A2 Recombinant Protein
Produktgrößen
20ug
£348,00
OPCA01475-20UG
100ug
£500,00
OPCA01475-100UG
1mg
£1822,00
OPCA01475-1MG
Über dieses Produkt
- SKU:
- OPCA01475
- Zusätzliche Namen:
- ATP2B;ATPase Ca++ transporting cardiac muscle slow twitch 2;ATPase; Ca++ dependent; slow-twitch; cardiac muscle-2;calcium pump 2;Calcium-transporting ATPase sarcoplasmic reticulum type; slow twitch skeletal muscle isoform;cardiac Ca2+ ATPase;DAR;DD;endoplasmic reticulum class 1/2 Ca(2+) ATPase;sarcoplasmic/endoplasmic reticulum calcium ATPase 2;SERCA2;SR Ca(2+)-ATPase 2.
- Weitere Details:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle (PubMed:16402920). Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS; thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation (By similarity).
- Gendetails:
- ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
- Host:
- Human
- Molekulargewicht:
- 52.3 kDa
- Proteindetails:
- Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
- Reinheit:
- Greater than 90% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php