ATG3 Recombinant Protein
Produktgrößen
20ug
£348,00
OPCA01474-20UG
100ug
£500,00
OPCA01474-100UG
1mg
£1822,00
OPCA01474-1MG
Über dieses Produkt
- SKU:
- OPCA01474
- Zusätzliche Namen:
- 2610016C12Rik;APG3;APG3 autophagy 3-like;APG3L;APG3-LIKE;ATG3 autophagy related 3 homolog;autophagy-related protein 3;hApg3;PC3-96;Protein PC3-96;ubiquitin-like-conjugating enzyme ATG3.
- Weitere Details:
- E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt); autophagy; and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP; GABARAPL1; GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme; catalyzing the conjugation of ATG12 to itself; ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
- Gendetails:
- autophagy related 3
- Host:
- Human
- Molekulargewicht:
- 51.9 kDa
- Proteindetails:
- Ubiquitin-like-conjugating enzyme ATG3
- Reinheit:
- Greater than 90% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php