AIFM1 Recombinant Protein
Produktgrößen
20ug
£348,00
OPCA01456-20UG
100ug
£500,00
OPCA01456-100UG
1mg
£1822,00
OPCA01456-1MG
Über dieses Produkt
- SKU:
- OPCA01456
- Zusätzliche Namen:
- AIF;apoptosis-inducing factor 1; mitochondrial;apoptosis-inducing factor; mitochondrion-associated; 1;auditory neuropathy; X-linked recessive 1;AUNX1;CMT2D;CMTX4;COWCK;COXPD6;DFNX5;NADMR;NAMSD;PDCD8;programmed cell death 8 (apoptosis-inducing factor);Programmed cell death protein 8;SEMDHL;striatal apoptosis-inducing factor;testicular secretory protein Li 4.
- Weitere Details:
- Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli; it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus; where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast; functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G;and thereby inhibits the EIF3 machinery and protein synthesis; and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent; pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.
- Gendetails:
- apoptosis inducing factor mitochondria associated 1
- Host:
- Human
- Molekulargewicht:
- 71.6 kDa
- Proteindetails:
- Apoptosis-inducing factor 1; mitochondrial
- Reinheit:
- Greater than 90% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php