DDX39B Recombinant Protein
Produktgrößen
100ug
£500,00
OPCA00324-100UG
Über dieses Produkt
- SKU:
- OPCA00324
- Zusätzliche Namen:
- 56 kDa U2AF65-associated protein;ATP-dependent RNA helicase p47;BAT1;D6S81E;DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B;DEAD box protein UAP56;DEAD-box helicase 39B;HLA-B-associated transcript 1 protein;nuclear RNA helicase (DEAD family);spliceosome RNA helicase BAT1;spliceosome RNA helicase DDX39B;UAP56.
- Weitere Details:
- Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription; processing and nuclear export; and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism; binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC and CHTOP onto mRNA. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Also associates with pre-mRNA independent of ALYREF/THOC4 and the THO complex. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability.
- Gendetails:
- DExD-box helicase 39B
- Molekulargewicht:
- 55.2 kDa
- Proteindetails:
- Spliceosome RNA helicase DDX39B
- Reinheit:
- Greater than 90% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Quelle:
- E.coli
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:html_datasheet.php